Abstract: The Glas G2 ENDS is a temperature-regulated nicotine salt pre-filled disposable pod connected system (Glas system). This work adopted the QRA approach to evaluate and present a comparison of reduced exposure (selective HPHCs) and corresponding potential cancer and non-cancer risks for the Glas G2 system with tobacco, menthol and non-tobacco-non-menthol formulations in comparison to the tobacco combustible reference cigarette, 3R4F and Market cigarettes, machine vaped/smoked under non- intense and intense puffing conditions.
Exposure concentrations (EC) were estimated assuming a lifetime continuous exposure using the equations. Tobacco cigarette: AC × CPD × ED × EF / DIR × AT
Glas ENDS: AC × (PC × PV) × ED × EF / DIR × AT
where EC, exposure concentration; AC, analyte concentrations under non-intense and intense conditions; CPD, cigarettes per day (20 for tobacco cigarettes); E, exposure duration (64.4 years); EF, exposure frequency (365 days); DIR, daily inhalation rate (20 m3/day); AT, averaging time (25550 days); PC, puff count (worst-case 400 puffs), and PV, puff volume (Glas: 0.055 Liter for non- intense and 0.11 Liter for intense and Tobacco cigarettes: 0.035 Liter ISO non-intense and 0.055 Liter Health Canada intense).
Non-cancer risks were quantified using the hazard quotient (HQ) approach and cancer risks were estimated by calculating the incremental lifetime cancer risk (ILCR), utilizing non-cancer and cancer toxicity values issued by government agencies or published in peer-reviewed literature. Data revealed that, the modelling of exposure to HPHCs in Glas ENDS products aerosols lead to a marked reduction when compared to the smoke from tobacco combustible cigarette under both non-intense and intense vaping conditions, indicating the potential for significant reduced (>99%) non-cancer and cancer health hazard risks.
Manoj Misra, Ed Carmines, Lise Fraissinet
Affiliations: Chemular, Inc, Hudson, MI, USA
